CD127

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone SB/199
Applications FC
Amount 0.025 mg
ArtNr 20-783-310371
Available
Genway ID:
GWB-4CB64D
Specificity:
CD127NCBI
Gene ID:
16197
Specificity:
CD127
Clone:
SB/199
Immunogen:
Pre-B cell line 1A9
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - 1/25 - 1/100
Function:
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Subunit:
The IL7 receptor is an heterodimer of IL7R and IL2RG. The TSLP receptor is an heterodimer of CRLF2 and IL7R.
Subcellular Location:
Isoform H20: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:
Isoform H1: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:
Isoform H6: Secreted.
Domain:
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
Domain:
The box 1 motif is required for JAK interaction and/or activation.
Disease:
Defects in IL7R are a cause of autosomal recessive severe combined immunodeficiency T-cell-negative/B-cell-positive/NK cell-positive (T(-)/B(+)/NK(+) SCID) [MIM:608971]. SCID refers to a genetically and clinically group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity leukopenia and low or absent antibody levels. Patients with SCID present in infancy with recurrent persistent infections by opportunistic organisms including Candida albicans Pneumocystis carinii and cytomegalovirus among many others. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
Disease:
A genetic variation in transmembrane domain of IL7R is associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. Overtransmission of the major \' C\' allele coding for Thr-244 are detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either \' C\' allele (Thr-244) or \' T\' allele (Ile-244) shows that the \' C\' allele results in an approximately two-fold increase in the skipping of exon 6 leading to increased production of a soluble form of IL7R. Thus the multiple sclerosis associated \' C\' risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population some additional triggers are probably required for the development and progression of MS.
Similarity:
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Similarity:
Contains 1 fibronectin type-III domain. 1. Kouro. T. et al. (2002) Relationship between early B-and NK-lineage lymphocyte precursors in bone marrow. 2. Yamashita. Y. et al. (1999) Syndecan-4 is expressed by B lineage lymphocytes and can transmit a signal for formation of dendritic processes.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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