EMR3


Hersteller	GENWAY
Kategorie	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Specific against	other
Clon	3D7
Applikationen	FC
Menge	0.025 mg
ArtNr	20-783-310518
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Genway ID:	GWB-5FEB94
Specificity:	EMR3
Specificity:	EMR3
Clone:	3D7
Immunogen:	ARHO-EMR3-CD97 (EGF1) transfectants.
Fusion Partner:	Spleen cells from immunised Armenian hamster were fused with cells of the mouse SP2/0 myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - Neat - 1/10
Function:	Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes-derived macrophages and activated neutrophils.
Subunit:	Forms a heterodimer consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit) (By similarity).
Subcellular Location:	Cell membrane; Multi-pass membrane protein.
Subcellular Location:	EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha: Secreted extracellular space. Note=A soluble form is also detected (alpha subunit).
Tissue Specificity:	Displays a predominantly leukocyte-restricted expression with highest levels in neutrophils monocytes and macrophages.
Ptm:	Proteolytically cleaved into 2 subunits an extracellular alpha subunit and a seven-transmembrane subunit (By similarity).
Similarity:	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily [view classification].
Similarity:	Contains 2 EGF-like domains.
Similarity:	Contains 1 GPS domain. 1. Stacey. M. et al. (2001) Human epidermal growth factor (EGF) module-containg mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognises a ligand on human macrophages and activated neutrophils. 2. Matmati. M. et al. (2007) The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes.

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Menge: 0.025 mg

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Lieferung vsl. bis 30.05.2024

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