Hersteller |
GENWAY
|
Kategorie |
|
Typ |
Antibody |
Specific against |
other |
Clon |
E11 |
Applikationen |
FC |
Menge |
0.025 mg |
ArtNr |
20-783-310696 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Genway ID: |
GWB-A7711D |
Specificity: |
CD35NCBI |
Gene ID: |
1378 |
Specificity: |
CD35 |
Clone: |
E11 |
Immunogen: |
Human acute monocytic leukaemia cells |
Fusion Partner: |
Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line. |
Preparation: |
Purified IgG prepared by ion exchange chromatography |
Buffer Solution: |
Phosphate buffered saline pH7. 4 |
|
Preservative Stabilisers: |
| 0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested |
Flow Cytometry: |
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested |
Dilution: |
Flow Cytometry - Neat |
Function: |
Mediates cellular binding of particles and immune complexes that have activated complement. |
Subunit: |
Monomer. |
Subcellular Location: |
Membrane; Single-pass type I membrane protein. |
Tissue Specificity: |
Present on erythrocytes leukocytes glomerular podocytes and splenic follicular dendritic cells. |
Polymorphism: |
CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting a process associated with cerebral malaria the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl(a)/Vil (Kn4 or Swain-Langley; Vil or Villien). Sl(a-) phenotype is more common in persons of African descent and may protect against fatal malaria. |
Miscellaneous: |
This is the sequence of the F allotype of CR1. |
Similarity: |
Belongs to the receptors of complement activation (RCA) family. |
Similarity: |
Contains 30 Sushi (CCP/SCR) domains. 1. Hogg. N. et al. (1984) Identification of an anti-monocyte monoclonal antibody that is specific for membrane complement receptor type one (CR1). 2. Yoshino. N. et al. (2000) Upgrading of flow cytometric analysis for absolute counts. cytokines and other antigenic molecules of Cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. 3. Birmingham. D. J. et al. (1996) The baboon erythrocyte complement receptor is a glycophosphatidylinositol-linked protein encoded by a homologue of the human CR1-like genetic element 4. Sopper. S. et al. (1997) Lymphocyte subsets and expression of differentiation markers in blood and lymphoid organs of Rhesus monkeys. Cytometry 29: 351-362. |
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