CD11b

CD11bNCBI

CD11b

T cell enriched splenocytes from B10 mice

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Suggested

Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3 the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Membrane; Single-pass type I membrane protein.

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Belongs to the integrin alpha chain family.

Contains 1 VWFA domain. 1. Springer. T. et al. (1978) Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. 2. Springer. T. et al. (1979) Mac-1: a macrophage differentiation antigen identified by a monoclonal antibody. 3. Beller. D. I. et al. (1982) Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor 4. Whiteland. J. L. et al. (1995) Immunohistochemical detection of T cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies. 5. Klingel. K. et al. (2003) Beta2-microglobulin-associated regulation of interferon-gamma and virus-specific immunoglobulin G confer resistance against the development of chronic coxsackievirus myocarditis.