CD45

CD45NCBI

CD45

Human T lymphocytes

This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. 1mM EDTA pH8. 0 is recommended for this purpose. Histology: Human Tonsil

Phosphate buffered saline pH7. 4

Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested

Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation recruits an dephosphorylates SKAP1 and FYN.

Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1.

The first PTPase domain interacts with SKAP1.

Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+)SCID) [MIM:608971]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity leukopenia and low or absent antibody levels. Patients with SCID present in infancy with recurrent persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.

Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.

Contains 2 tyrosine-protein phosphatase domains. 1. Dalchau. R. et al. (1980) Monoclonal antibody to a human leukocyte-specific membrane glycoprotein probably homologous to the leukocyte-common (L-C) antigen of the rat 2. Quenby. S et al. (1999) Pre-implantation endometrial leukocytes in women with recurrent miscarriage.