AGGRECAN


ArtNr	20-783-70530
Hersteller	GENWAY
Menge	2 ml
Kategorie	Oncology Antibodies Immunohistochemistry Immunoprecipitation ELISA Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Applikationen	IP, IHC, ELISA
Clon	MA75A95 (HAG
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-DBA7B3
Similar products	20-783-70530
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Genway ID:	GWB-DBA7B3
Specificity:	AGGRECANNCBI
Gene ID:	176
Specificity:	AGGRECAN
Clone:	MA75A95 (HAG7E1)
Immunogen:	Human cartilage aggrecan
Fusion Partner:	Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Specificity Note:	This product recognises human aggrecan a proteoglycan component of cartilage matrix. The antibody reacts with both adult and fetal cartilage matrix in immunohistology.
Preparation:	Tissue Culture Supernatant containing 0. 2M Tris/HCl pH7. 4 and 5-10% foetal calf serum
Preservative Stabilisers:		0. 09%Sodium Azide
Function:	This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
Subunit:	Interacts with FBLN1 (By similarity).
Subcellular Location:	Secreted extracellular space extracellular matrix (By similarity).
Domain:	Two globular domains G1 and G2 comprise the N-terminus of the proteoglycan while another globular region G3 makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A B B\' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.
Ptm:	Contains mostly chondroitin sulfate but also keratan sulfate chains N-linked and O-linked oligosaccharides.
Similarity:	Belongs to the aggrecan/versican proteoglycan family.
Similarity:	Contains 1 C-type lectin domain.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Similarity:	Contains 4 Link domains.
Similarity:	Contains 1 Sushi (CCP/SCR) domain.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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