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PROTEIN KINASE C ALPHA

PROTEIN KINASE C ALPHA

ArtNr	20-783-70710
Hersteller	GENWAY
Menge	2 ml
Kategorie	Oncology Neuroscience Metabolism Diabetes Targets for Rodent Neurosciences Neural Signaling Antibodies By Cell Type Melanoma Immunohistochemistry Western Blot Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	WB, IHC
Clon	133
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-FA9878
Similar products	20-783-70710
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Genway ID:	GWB-FA9878
Specificity:	PROTEIN KINASE C ALPHA
Specificity:	PROTEIN KINASE C ALPHA
Clone:	133
Immunogen:	Protein kinase C alpha
Fusion Partner:	Spleen cells from immunised mice were fused with cells of the mouse SP2/0 myeloma cell line.
Specificity Note:	This product recognises the a isoform of protein kinase C. This antibody recognises the sequence PQFVHPILQSAV at the C terminus of PKCa.
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Dilution:	Suggested
Dilution:	Immunohistology - Frozen - Nt - 1/10Western Blotting - 1/10 - 1/500
Function:	This is a calcium-activated phospholipid-dependent serine- and threonine-specific enzyme. May play a role in cell motility by phosphorylating CSPG4.
Function:	PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters a class of tumor promoters.
Catalytic Activity:	ATP + a protein = ADP + a phosphoprotein. Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
Subunit:	Interacts with CENTA1 CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine.
Similarity:	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:	Contains 1 AGC-kinase C-terminal domain.
Similarity:	Contains 1 C2 domain.
Similarity:	Contains 2 phorbol-ester/DAG-type zinc fingers.
Similarity:	Contains 1 protein kinase domain.

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