NUCLEAR ANTIGEN


ArtNr	20-783-73549
Hersteller	GENWAY
Menge	0.1 ml
Kategorie	Oncology Antibodies Immunofluorescence Primary Antibodies By Organ Bladder Cancer
Typ	Antibody
Applikationen	IF
Clon	58-15
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D1E67B
Similar products	20-783-73549
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Genway ID:	GWB-D1E67B
Specificity:	NUCLEAR ANTIGEN
Specificity:	NUCLEAR ANTIGEN
Clone:	58-15
Immunogen:	Nuclear material from lymphoma cells
Specificity Note:	This product recognizes nuclear ribonucleoprotein particles in human cells. Ribonucleoprotein (RNP) is a nucleoprotein that contains RNA i. e. it is an association that combines ribonucleic acid and protein together. A few examples are known like the ribosome the enzyme telomerase and small nuclear RNPs (snRNPs).
Preparation:	Ig fraction prepared by ammonium sulphate precipitation
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 09%Sodium Azide (NaN3) Suggested
Dilution:	Suggested
Dilution:	Immunofluorescence - 1/20 - 1/30
Function:	This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase\' s processibility during elongation of the leading strand.
Subunit:	Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH POLK DNMT1 ERCC5/XPG FEN1 CDC6 APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1 POLD3 and POLD4.
Subcellular Location:	Nucleus.
Ptm:	Upon methyl methanesulfonate-induced DNA damage mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through \' Lys-63\' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligase SHPRH whih is required for DNA repair.
Disease:	Antibodies are present in sera from patients with systemic lupus erythematosus.
Similarity:	Belongs to the PCNA family. 1. Clevenger. C. V. et al. (1985) A method for simultaneous nuclear immunofluorescence and DNA content quantitation using monoclonal antibodies and flow cytometry.

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