NUCLEAR ANTIGEN


Item no.	20-783-73549
Manufacturer	GENWAY
Amount	0.1 ml
Category	Oncology Antibodies Immunofluorescence Primary Antibodies By Organ Bladder Cancer
Type	Antibody
Applications	IF
Clone	58-15
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D1E67B
Similar products	20-783-73549
Available
Genway ID:	GWB-D1E67B
Specificity:	NUCLEAR ANTIGEN
Specificity:	NUCLEAR ANTIGEN
Clone:	58-15
Immunogen:	Nuclear material from lymphoma cells
Specificity Note:	This product recognizes nuclear ribonucleoprotein particles in human cells. Ribonucleoprotein (RNP) is a nucleoprotein that contains RNA i. e. it is an association that combines ribonucleic acid and protein together. A few examples are known like the ribosome the enzyme telomerase and small nuclear RNPs (snRNPs).
Preparation:	Ig fraction prepared by ammonium sulphate precipitation
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 09%Sodium Azide (NaN3) Suggested
Dilution:	Suggested
Dilution:	Immunofluorescence - 1/20 - 1/30
Function:	This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase\' s processibility during elongation of the leading strand.
Subunit:	Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH POLK DNMT1 ERCC5/XPG FEN1 CDC6 APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1 POLD3 and POLD4.
Subcellular Location:	Nucleus.
Ptm:	Upon methyl methanesulfonate-induced DNA damage mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through \' Lys-63\' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligase SHPRH whih is required for DNA repair.
Disease:	Antibodies are present in sera from patients with systemic lupus erythematosus.
Similarity:	Belongs to the PCNA family. 1. Clevenger. C. V. et al. (1985) A method for simultaneous nuclear immunofluorescence and DNA content quantitation using monoclonal antibodies and flow cytometry.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 ml

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Delivery expected until 10/30/2025

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