CD4


ArtNr	20-783-74864
Hersteller	GENWAY
Menge	0.5 mg
Kategorie	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	FC
Clon	YTS177. 9
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-E74090
Similar products	20-783-74864
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Genway ID:	GWB-E74090
Specificity:	CD4NCBI
Gene ID:	12504
Specificity:	CD4
Clone:	YTS177. 9
Immunogen:	Mouse spleen cells
Fusion Partner:	Spleen cells from immunised DA rats were fused with cells of the Y3/Ag1. 2. 3 rat myeloma cell line.
Specificity Note:	This product recognises murine CD4 a 55kD cell surface antigen expressed by a subset of T lymphocytes. The antibody is reported to block MHC class II dependant T-cell responses in vitro and in vivo and induces tolerance.
Preparation:	Purified IgG fraction prepared by ammonium sulphate precipitation
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		None presentSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - 1/50 - 1/200
Function:	Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subunit:	Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with and sequesters CD4 in the endoplasmic reticulum.
Ptm:	Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Miscellaneous:	Primary receptor for HIV-1.
Similarity:	Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Qin. S. et al. (1990) Induction of tolerance in peripheral T-cells with monoclonal antibodies. 2. Cobbold. S. P. et al. (1990) The induction of skin graft tolerance in MHC-mismatched or primed recipients: primed T-cells can be tolerised in the periphery with CD4 and CD8 antibodies. 3. Wise. M. P. et al. (1998) Cutting Edge: Linked suppression of skin graft rejection can operate through indirect recognition.

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Menge: 0.5 mg

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