Calbindin D28

Rabbit IgG

A synthetic peptide corresponding to aa 185-199 of human Calbinin-D-28K protein. Calbindin-D-28K (also termed vitamin D-dependent calcium-binding protein or cholecalcin) is a highly conserved 28kDa calcium binding protein with broad tissue distribution. It belongs together with calmodulin S-100 parvalbumin troponin C and other proteins to a family of low molecular weight calcium-binding proteins (CaBPs). These CaBPs have homologous primary structures which contain conserved polypeptide folds of the EFhand type for Ca2+ binding. Calbindin-D-28K is found predominantly in subpopulations of central and peripheral nervous system neurons and in certain epithelial nervous system neurons and in certain epithelial cells involved in Ca2+ transport such as distal tubular cells and cortical collecting tubules of the kidney and in enteric neuroendocrine cells.