MOUSE ANTI RAT CD62L

CD62L

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia By similarity. Subunit structureInteraction with PSGL1/SELPLG is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan and tyrosine sulfation modifications of PSGL1 By similarity. Subcellular locationMembrane; Single-pass type I membrane protein. Tissue specificityExpressed in peripheral blood mononuclear cells (PBMC) spleen and thymus. Ref. 1Induction: Down-regulated by mitogen stimulation of PBMC and spleen T-cells. Ref. 1Sequence similaritiesBelongs to the selectin/LECAM family. Contains 1 C-type lectin domain. Contains 1 EGF-like domain. Contains 2 Sushi (CCP/SCR) domains.