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PKC-beta(Phospho-Thr642) Antibody Blocking Peptide

PKC-beta(Phospho-Thr642) Antibody Blocking Peptide

ArtNr	06-785-213145
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Metabolism Diabetes By Cell Type Melanoma Peptides & Proteins Peptides
Typ	Peptides
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-D87166
Similar products	06-785-213145
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Genway ID:	GWB-D87166
Function:	This is a calcium-activated phospholipid-dependent serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B-cells after BCR cross-linking (By similarity).
Catalytic Activity:	ATP + a protein = ADP + a phosphoprotein. Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
Subunit:	Interacts with PDK1 (By similarity). Interacts in vitro with PRKCBP1.
Subcellular Location:	Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
Ptm:	Phosphorylation on Thr-500 of isoform beta-I within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Similarly isoform beta-II is autophosphorylated on \' Thr-640\' and \' Ser-659\' subsequent to phosphorylation on Thr-500. Autophosphorylated on other sites i. e. in the N-terminal and hinge regions have no effect on PKC activity (By similarity).
Similarity:	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:	Contains 1 AGC-kinase C-terminal domain.
Similarity:	Contains 1 C2 domain.
Similarity:	Contains 2 phorbol-ester/DAG-type zinc fingers.
Similarity:	Contains 1 protein kinase domain.

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Menge: 0.1 mg

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