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PKC-beta(Phospho-Thr642) Antibody Blocking Peptide

PKC-beta(Phospho-Thr642) Antibody Blocking Peptide

Item no.	06-785-213145
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Metabolism Diabetes By Cell Type Melanoma Peptides & Proteins Peptides
Type	Peptides
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-D87166
Similar products	06-785-213145
Available
Genway ID:	GWB-D87166
Function:	This is a calcium-activated phospholipid-dependent serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B-cells after BCR cross-linking (By similarity).
Catalytic Activity:	ATP + a protein = ADP + a phosphoprotein. Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
Subunit:	Interacts with PDK1 (By similarity). Interacts in vitro with PRKCBP1.
Subcellular Location:	Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
Ptm:	Phosphorylation on Thr-500 of isoform beta-I within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Similarly isoform beta-II is autophosphorylated on \' Thr-640\' and \' Ser-659\' subsequent to phosphorylation on Thr-500. Autophosphorylated on other sites i. e. in the N-terminal and hinge regions have no effect on PKC activity (By similarity).
Similarity:	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:	Contains 1 AGC-kinase C-terminal domain.
Similarity:	Contains 1 C2 domain.
Similarity:	Contains 2 phorbol-ester/DAG-type zinc fingers.
Similarity:	Contains 1 protein kinase domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 11/13/2025

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