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AMPK1/AMPK2 (Phospho-Ser485/ Ser491) Antibody Blocking Peptide

AMPK1/AMPK2 (Phospho-Ser485/ Ser491) Antibody Blocking Peptide

Catalytic
ArtNr	06-785-213147
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Metabolism By Cell Type Hematology Lymphoma Peptides & Proteins Cell Biology Obesity Cell Status Autophagy Peptides
Typ	Peptides
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-C21E16
Similar products	06-785-213147
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Genway ID:	GWB-C21E16
Form of Peptide:	Peptide in 10 mM phosphate buffered saline (without Mg2+ and Ca2+) pH 7. 4 150mM NaCl 0. 1 mM EDTA 1 mg/ml BSA 5% DMF and 5% glycerol. Peptide Information: The synthesized phosphopeptide was derived from human AMPK1/AMPK2around the phosphorylation site of serine 485/491 (S-G- SP-V-S). Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and mass spectrometry.
Specificity:	The peptide specifically blocks the signal of AMPK1/AMPK2 (Phospho-Ser485/Ser491) antibody (#11174) completely in Western blotting and IHC.
Applications:	For
Western Blotting:	add 10 ?l of antibody and 10 ?l of blocking peptide to 10 ml of antibody dilution buffer and incubate at 4? over night or at room temperature for 2 hours before allowing to react with the blot.
Function:	Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5\' -AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
Activity:	ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium.
Enzyme Regulation:	Binding of AMP results in allosteric activation inducing phosphorylation on Thr-174 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. Also activated by phosphorylation by CAMKK2 triggered by a rise in intracellular calcium ions without detectable changes in the AMP/ATP ratio.
Subunit:	Heterotrimer of an alpha catalytic subunit a beta and a gamma non-catalytic subunits. Interacts with FNIP1 and FNIP2.
Similarity:	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Similarity:	Contains 1 protein kinase domain.

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Menge: 0.1 mg

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Lieferung vsl. bis 30.10.2025

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