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SNRP70 (small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen))

SNRP70 (small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen))

ArtNr	18-003-43558
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Infectious Diseases Viral Infections Coronavirus (COVID-19) Peptides & Proteins Immunohistochemistry Western Blot Peptides
Typ	Peptides
Applikationen	WB, IHC
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-AE2778
Similar products	18-003-43558
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Genway ID:	GWB-AE2778
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human SNRP70. Western Blot: Suggested dilution at 0. 25 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50. 000 - 100. 000 as second antibody.
ELISA Titre:	1:62500
Category:	RNA Binding Proteins
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. SNRP70 contains 1 RRM (RNA recognition motif) domain and mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.
Function:	Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
Subunit:	Found in a pre-mRNA splicing complex with SFRS4 SFRS5 SNRP70 SNRPA1 SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SFRS10 SNRP70 SNRPA1 and SRRM1. Interacts with dephosphorylated FUSIP1 and SFPQ. Interacts with NUDT21/CPSF5 CPSF6 SFRS2IP and ZRANB2.
Subcellular Location:	Nucleus.
Ptm:	The N-terminus is blocked.
Ptm:	Extensively phosphorylated on serine residues in the C-terminal region.
Disease:	Major ribonucleoprotein antigen recognized by the sera from patients with autoimmune diseases such as systemic lupus erythematosus.
Similarity:	Contains 1 RRM (RNA recognition motif) domain. Brandenberger. R. . (2004) Nat. Biotechnol. 22 (6). 707-716.

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