Human Vitronectin

ArtNr	11-511-248731
Hersteller	GENWAY
Menge	10ml
Kategorie	Oncology Neuroscience Neural Adhesion Molecules Infectious Diseases Viral Infections Coronavirus (COVID-19) Peptides & Proteins Recombinant Proteins Cell Biology Cell Stainings ECM By Organ Breast Cancer
Typ	Proteins
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-62DE78
Similar products	11-511-248731
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Genway ID:	GWB-62DE78
Specificity:	Vitronectin
Type of Product:	Purified Platelets and Hemostasis Antigens
Inactivation:	Not applicable
Buffer:	0. 05M Sodium phosphate pH 7. 4 containing 0. 1M Sodium chlorideApplications Notes : Second order rate constants for inhibition of:. uPA = 6. 3 x 106 M-1s-1. tPA = 5. 7 x 106 M-1s-1
Concentration:	Concentration is lot specific Human Vitronectin
Function:	Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Function:	Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
Subunit:	Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin.
Subcellular Location:	Secreted extracellular space.
Tissue Specificity:	Plasma.
Domain:	The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
Ptm:	Sulfated on 2 tyrosine residues.
Ptm:	N- and O-glycosylated (By similarity).
Ptm:	Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
Ptm:	It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Similarity:	Contains 4 hemopexin-like domains.
Similarity:	Contains 1 SMB (somatomedin-B) domain.

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