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Human Vitronectin

Human Vitronectin

Item no.	11-511-248731
Manufacturer	GENWAY
Amount	10ml
Category	Oncology Neuroscience Neural Adhesion Molecules Infectious Diseases Viral Infections Coronavirus (COVID-19) Peptides & Proteins Recombinant Proteins Cell Biology Cell Stainings ECM By Organ Breast Cancer
Type	Proteins
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-62DE78
Similar products	11-511-248731
Available
Genway ID:	GWB-62DE78
Specificity:	Vitronectin
Type of Product:	Purified Platelets and Hemostasis Antigens
Inactivation:	Not applicable
Buffer:	0. 05M Sodium phosphate pH 7. 4 containing 0. 1M Sodium chlorideApplications Notes : Second order rate constants for inhibition of:. uPA = 6. 3 x 106 M-1s-1. tPA = 5. 7 x 106 M-1s-1
Concentration:	Concentration is lot specific Human Vitronectin
Function:	Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Function:	Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
Subunit:	Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin.
Subcellular Location:	Secreted extracellular space.
Tissue Specificity:	Plasma.
Domain:	The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
Ptm:	Sulfated on 2 tyrosine residues.
Ptm:	N- and O-glycosylated (By similarity).
Ptm:	Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
Ptm:	It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Similarity:	Contains 4 hemopexin-like domains.
Similarity:	Contains 1 SMB (somatomedin-B) domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10ml

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Delivery expected until 9/11/2025

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