ANGIOTENSIN IV

ArtNr	10-783-79479
Hersteller	GENWAY
Menge	5 mg
Kategorie	Peptides & Proteins Recombinant Proteins ELISA Cardiovascular Research Heart Failure Myocardial Infarction Hypertension
Typ	Proteins
Applikationen	ELISA
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-AC956A
Similar products	10-783-79479
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Genway ID:	GWB-AC956A
Specificity:	ANGIOTENSIN IVNCBI
Gene ID:	183 Peptide
Sequence:	VYIHPFDescription: Angiotensin is a hexapeptide found in the blood that is responsible for vasoconstriction increased blood preseeure and release of aldosterone from the adrenal cortex.
Preparation:	Solid phase synthesis
Buffer Solution:	Acetate salt
Function:	In response to lowered blood pressure the enzyme renin cleaves angiotensin-1 from angiotensinogen. ACE (angiotensin converting enzyme) then removes a dipeptide to yield the physiologically active peptide angiotensin-2 the most potent pressor substance known which helps regulate volume and mineral balance of body fluids.
Function:	Angiotensin-3 stimulates aldosterone release.
Subunit:	During pregnancy exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.
Subcellular Location:	Secreted.
Tissue Specificity:	Expressed by the liver and secreted in plasma.
Disease:	Defects in AGT are associated with susceptibility to essential hypertension [MIM:145500]. Hypertension also occurs in 5-7% of all pregnancies where it is a leading cause of maternal fetal and neonatal morbidity and mortality. Among pregnancy-induced hypertension cases severe preeclampsia [MIM:189800] is characterized by the development of hypertension and proteinuria after the 20th week of pregnancy and is the most distinctive life-threatening form.
Disease:	Defects in AGT are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Similarity:	Belongs to the serpin family. 1. Wright. J. W. et al. (1995) The angiotensin IV system: functional implications.

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