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ANGIOTENSIN IV

ANGIOTENSIN IV

Item no.	10-783-79479
Manufacturer	GENWAY
Amount	5 mg
Category	Peptides & Proteins Recombinant Proteins ELISA Cardiovascular Research Heart Failure Myocardial Infarction Hypertension
Type	Proteins
Applications	ELISA
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-AC956A
Similar products	10-783-79479
Available
Genway ID:	GWB-AC956A
Specificity:	ANGIOTENSIN IVNCBI
Gene ID:	183 Peptide
Sequence:	VYIHPFDescription: Angiotensin is a hexapeptide found in the blood that is responsible for vasoconstriction increased blood preseeure and release of aldosterone from the adrenal cortex.
Preparation:	Solid phase synthesis
Buffer Solution:	Acetate salt
Function:	In response to lowered blood pressure the enzyme renin cleaves angiotensin-1 from angiotensinogen. ACE (angiotensin converting enzyme) then removes a dipeptide to yield the physiologically active peptide angiotensin-2 the most potent pressor substance known which helps regulate volume and mineral balance of body fluids.
Function:	Angiotensin-3 stimulates aldosterone release.
Subunit:	During pregnancy exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg.
Subcellular Location:	Secreted.
Tissue Specificity:	Expressed by the liver and secreted in plasma.
Disease:	Defects in AGT are associated with susceptibility to essential hypertension [MIM:145500]. Hypertension also occurs in 5-7% of all pregnancies where it is a leading cause of maternal fetal and neonatal morbidity and mortality. Among pregnancy-induced hypertension cases severe preeclampsia [MIM:189800] is characterized by the development of hypertension and proteinuria after the 20th week of pregnancy and is the most distinctive life-threatening form.
Disease:	Defects in AGT are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Similarity:	Belongs to the serpin family. 1. Wright. J. W. et al. (1995) The angiotensin IV system: functional implications.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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