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MMP10 Antibody (C-term)

MMP10 Antibody (C-term)

ArtNr	ABC-AP6194a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MMP10, STMY2, Stromelysin-2, Matrix metalloproteinase-10, Transin-2, MMP-10, SL-2
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Primary Accession	P09238
Antigen Type	Synthetic Peptide
Application	WB, IHC-P
Bio Background	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP10 degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Bio References	Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999). Pendas, A.M., et al., Genomics 37(2):266-268 (1996). Jung, J.Y., et al., Ann. Genet. 33(1):21-23 (1990). Sirum, K.L., et al., Biochemistry 28(22):8691-8698 (1989). Muller, D., et al., Biochem. J. 253(1):187-192 (1988).
Clonality	Polyclonal
Clone/Animal Names	RB2022
Gene ID	4319
Gene Name	MMP10
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of hMMP10-R409 (Cat. #AP6194a) in mouse spleen tissue lysates (35ug/lane). MMP10 (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Other Accession	NP_002416
Isotype	Rabbit Ig
Calculated MW	54151
Antigen Region	394-423
Antigen Source	HUMAN
Target/Specificity	This MMP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-423 amino acids from the C-terminal region of human MMP10.
NCBI Accession	NP_002416.1

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Menge: 400 ul

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