GRB2 Antibody (Y209)

ArtNr	ABC-AP6283a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	GRB2, ASH, Growth factor receptor-bound protein 2, Adapter protein GRB2, SH2/SH3 adapter GRB2, Protein Ash
Lieferbar
Primary Accession	P62993
Antigen Type	Synthetic Peptide
Application	WB, IHC-P
Bio Background	GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway.
Bio References	Kondo, A., J. Biol. Chem. 283 (3), 1428-1436 (2008) Morimatsu, M., Proc. Natl. Acad. Sci. U.S.A. 104 (46), 18013-18018 (2007) Martinez, N., Cell. Signal. 19 (11), 2277-2285 (2007)
Clonality	Polyclonal
Clone/Animal Names	RB11305-11306
Gene ID	2885
Gene Name	GRB2
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of lysate from Ramos cell line, using GRB2 Antibody (pY209)(Cat. #AP6283a). AP6283a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with GRB2 Antibody (Y209), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	P62994; Q60631; Q07883; Q6GPJ9; P87379
Predicted	X, C, M, Rat
Isotype	Rabbit Ig
Calculated MW	25206
Antigen Region	187-216
Antigen Source	HUMAN
Target/Specificity	This GRB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from human GRB2.
NCBI Accession	NP_002077.1; NP_987102.1

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ABC-AP6283a-datasheet.pdf

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Menge: 400 ul

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