TTR Antibody (Center)

Synthetic Peptide

Transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

Polyclonal

7276

Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of TTR Antibody (Center) (Cat. #AP6698c) in HepG2 cell line lysates (35ug/lane). TTR (arrow) was detected using the purified Pab.

1:1000

IHC-P

TTR Antibody (Center) (Cat.#AP6698c) flow cytometry analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

1:10~50

B

15887

HUMAN

NP_000362.1