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LATS1 Antibody (N-term)

LATS1 Antibody (N-term)

ArtNr	ABC-AP7035a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Iida, S., et al., Oncogene 23(31):5266-5274 (2004). Yang, X., et al., Nat. Cell Biol. 6(7):609-617 (2004). Kamikubo, Y., et al., J. Biol. Chem. 278(20):17609-17614 (2003). Hisaoka, M., et al., Lab. Invest. 82(10):1427-1435 (2002). Hirota, T., et al., J. Cell Biol. 149(5):1073-1086 (2000).
NCBI	NP_001257448.1,NP_004681.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Serine/threonine-protein kinase LATS1,Large tumor suppressor homolog 1,WARTS protein kinase,h-warts,LATS1 {ECO:0000312\|EMBL:AAD168821}
Similar products	Serine/threonine-protein kinase LATS1, Large tumor suppressor homolog 1, WARTS protein kinase, h-warts, LATS1 {ECO:0000312\|EMBL:AAD168821}
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Manufacturer - Category	Primary Antibodies; Cancer; Cell Biology; Signal Transduction
Manufacturer - Targets	This LATS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LATS1.
Bio Background	The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB3029
Gene Name	LATS1 {ECO:0000312\|EMBL:AAD16882.1}
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M, Rat
Calculated Molecular Weight	126870
Antigen Source	HUMAN
Antigen Region	1-30
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Dilution	WB: 1:1000 IHC-P: 1:50~100
Antigen Type	Synthetic Peptide

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 400 ul

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