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GIPR Antibody (N-term)

GIPR Antibody (N-term)

ArtNr	ABC-AP7495A
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	GIPR, Gastric inhibitory polypeptide receptor, GIP-R, Glucose-dependent insulinotropic polypeptide receptor
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Primary Accession	P48546
Antigen Type	Synthetic Peptide
Application	WB, FC, IHC-P
Bio Background	GIPR also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. This protein was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. The protein is involved in several other facets of the anabolic response.
Bio References	Herbach, N. Am. J. Physiol. Renal Physiol. 296 (4), F819-F829 (2009) Rudovich, N., Kaiser, S. Regul. Pept. 142 (3), 138-145 (2007) Nitz, I., Fisher, E. Mol Nutr Food Res 51 (8), 1046-1052 (2007)
Clonality	Polyclonal
Clone/Animal Names	RB18125
Gene ID	2696
Gene Name	GIPR
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of GIPR antibody (N-term) (Cat.#AP7495a) in HL60 cell line lysates (35ug/lane). GIPR (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	GIPR Antibody (N-term) (Cat. #AP7495A)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GIPR Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Legend image 3	GIPR Antibody (Center) (Cat. #AP7495a) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Isotype	Rabbit Ig
Calculated MW	53157
Antigen Region	7-38
Antigen Source	HUMAN
Target/Specificity	This GIPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-38 amino acids from the N-terminal region of human GIPR.
NCBI Accession	NP_000155.1

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