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BRD4 Antibody (C-term)

BRD4 Antibody (C-term)

ArtNr	ABC-AP8051b
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	BRD4, HUNK1, Bromodomain-containing protein 4, Protein HUNK1
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Primary Accession	O60885
Antigen Type	Synthetic Peptide
Application	IHC-P
Bio Background	BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. The gene has been implicated as the chromosome 19 target of translocation t(15; 19)(q13; p13.1), which defines an upper respiratory tract carcinoma in young people.
Bio References	Maruyama, T., et al., Mol. Cell. Biol. 22(18):6509-6520 (2002). French, C.A., et al., Am. J. Pathol. 159(6):1987-1992 (2001). Dey, A., et al., Mol. Cell. Biol. 20(17):6537-6549 (2000).
Clonality	Polyclonal
Clone/Animal Names	RB3422
Gene ID	23476
Gene Name	BRD4
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 1	IHC-P
Dilution image 1	1:50~100
Legend image 2	Subnuclear distribution of cellular proteins. CHOBgl40 cells grown on coverslips were either directly or after treatment with 0.5% Triton X-100, incubated with antibodies against Brd4 (images 4 and 5). PI, propidium iodide staining of cellular DNA (images 6).WC, whole cells.
Type image 2	IHC-P
Dilution image 2	1:50~100
Other Accession	Q9ESU6
Predicted	M
Isotype	Rabbit Ig
Calculated MW	152219
Antigen Region	1313-1342
Antigen Source	HUMAN
Target/Specificity	This BRD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1313~1342 amino acids from the C-terminal region of human BRD4.
NCBI Accession	NP_055114.1; NP_490597.1

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ABC-AP8051b-datasheet.pdf

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Menge: 400 ul

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