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FLCN Antibody (Center)

FLCN Antibody (Center)

ArtNr	ABC-AP8658c
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Folliculin, FLCN, BHD, BHD skin lesion fibrofolliculoma protein, Birt-Hogg-Dube syndrome protein
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Primary Accession	Q8NFG4
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	FLCN may play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). FLCN may be a tumor suppressor. May be involved in colorectal tumorigenesis. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways.
Bio References	Khoo, S.K., et.al., J. Med. Genet. 39 (12), 906-912 (2002) Shin, J.H., et.al., J. Med. Genet. 40 (5), 364-367 (2003)
Clonality	Polyclonal
Clone/Animal Names	RB20959
Gene ID	201163
Gene Name	FLCN {ECO:0000303\|PubMed:15657874, ECO:0000312\|HGNC:HGNC:27310}
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of FLCN Antibody (Center) (Cat. #AP8658c) in CEM cell line lysates (35ug/lane). FLCN (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human lung carcinoma reacted with FLCN Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:50~100
Isotype	Rabbit Ig
Calculated MW	64473
Antigen Region	325-354
Antigen Source	HUMAN
Target/Specificity	This FLCN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-354 amino acids from the Central region of human FLCN.
NCBI Accession	NP_653207.1; NP_659434.2

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ABC-AP8658c-datasheet.pdf

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Menge: 400 ul

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Lieferung vsl. bis 06.11.2025

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