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FLCN Antibody (Center)

FLCN Antibody (Center)

Item no.	ABC-AP8658c
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Folliculin, FLCN, BHD, BHD skin lesion fibrofolliculoma protein, Birt-Hogg-Dube syndrome protein
Available
Primary Accession	Q8NFG4
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	FLCN may play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). FLCN may be a tumor suppressor. May be involved in colorectal tumorigenesis. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways.
Bio References	Khoo, S.K., et.al., J. Med. Genet. 39 (12), 906-912 (2002) Shin, J.H., et.al., J. Med. Genet. 40 (5), 364-367 (2003)
Clonality	Polyclonal
Clone/Animal Names	RB20959
Gene ID	201163
Gene Name	FLCN {ECO:0000303\|PubMed:15657874, ECO:0000312\|HGNC:HGNC:27310}
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of FLCN Antibody (Center) (Cat. #AP8658c) in CEM cell line lysates (35ug/lane). FLCN (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human lung carcinoma reacted with FLCN Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:50~100
Isotype	Rabbit Ig
Calculated MW	64473
Antigen Region	325-354
Antigen Source	HUMAN
Target/Specificity	This FLCN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-354 amino acids from the Central region of human FLCN.
NCBI Accession	NP_653207.1; NP_659434.2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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