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PE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein

PE-Labeled Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein

ArtNr	HL1-HP2E6-25tests
Hersteller	ACROBiosystems
Menge	25 tests
Quantity options	200 tests 25 tests
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	HIS, PE
Formula	0.2% BSA
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein / Fluorescent labeled protein
Manufacturer - Conjugate / Tag	C-10xHis, PE Labeled
Shipping Temperature	RT
Storage Conditions	-20°C, avoid light
Molecular Weight	36.3 kDa and 13.8 kDa
Manufacturer - Format	Powder
Description	PE-Labeled Human HLA-A02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein (HL1-HP2E6) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Ile 308 (HLA-A02:01) & Ile 21 - Met 119 (B2M) & SLLMWITQV peptide (Accession # AAA59606.1 (HLA-A*02:01) & P61769-1 (B2M) & SLLMWITQV).
Background	NY-ESO-1, which is also well-known as New York esophageal squamous cell carcinoma 1, is an efficient target for cancer immunotherapy. This antigen is a member of cancer-testis antigens (CTAs) and is highly expressed in various cancers, including melanoma, ovarian, cervical cancer, etc. Adoptive T cell therapy with HLA-A2 restricted NY-ESO-1 transduced CD8+ T cells has improved the clinical response rates and overall survival of treatment-refractory melanoma patients. The Human HLA-A0201 NY-ESO-1 (SLLMWITQV) complex protein is a complex of HLA-A0201 of the MHC Class I, B2M and SLLMWITQV peptide of the NY-ESO-1.
Molecule	HLA-A*0201 \| B2M \| NY-ESO-1
Exp Region	Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & SLLMWITQV peptide
Characteristics	PE-Labeled Human HLA-A02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein is assembled by biotinylated monomer (HL1-H82E4) and PE-labeled streptavidin.Biotinylated Human HLA-A02:01&B2M&NY-ESO-1 (SLLMWITQV) Complex Protein is produced by co-expression of HLA and B2M loaded with NY-ESO-1 peptide. Biotinylated Human HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).
Buffer	0.2% BSA
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

HL1-HP2E6-25tests-datasheet.pdf

HL1-HP2E6-25tests-safety-datasheet.pdf