Selnoflast

ArtNr	HY-132831-10mg
Hersteller	MedChem Express
CAS-Nr.	2260969-36-4
Menge	10 mg
Quantity options	100 mg 10 mM x 1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Kategorie	Reagents & Chemicals Biochemicals
Typ	Chemicals
Specific against	other
Purity	99.46
Formula	C20H29N3O3S
Citations	[1]Vande Walle L, et al. Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets. Nat Rev Drug Discov. 2023 Nov 29. [2]Klughammer B, et al. A randomized, double-blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to severe active ulcerative colitis. Clin Transl Med. 2023 Nov;13(11):e1471. [3]McManus RM, et al. NLRP3 inflammasome signalling in Alzheimer's disease[J]. Neuropharmacology. 2024 Jul 1;252:109941. [4]Teske KA, et al. Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays[J]. Cell Chem Biol. 2024 Feb 15;31(2):349-360.e6. [5]Zhang L, et al. Role of NLRP3 inflammasome in central nervous system diseases[J]. Cell Biosci. 2024 Jun 7;14(1):75.
Smiles	O=C(NS(=O)(C1CCN(CC1)CC)=O)NC2=C(CCC3)C3=CC4=C2CCC4
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Somalix, RO-7486967, IZD334
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Interleukin Related; NOD-like Receptor (NLR)
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	391.53
Product Description	Selnoflast (RO7486967), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule NLRP3 inflammasome inhibitor. Selnoflast is a potent inhibitor of IL-1β release stimulated by NLRP3 activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease[1][2][3][4][5]
Manufacturer - Research Area	Inflammation/Immunology; Neurological Disease
Solubility	1M NaOH : 3.33 mg/mL (adjust pH to 12 with 1M NaOH)\|DMSO : 5 mg/mL (ultrasonic; adjust pH to 8 with 1M NaOH)
Manufacturer - Pathway	Immunology/Inflammation
Isoform	NLRP3
Clinical information	No Development Reported

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HY-132831-10mg-safety-datasheet.pdf