Cyclophosphamide

ArtNr	HY-17420-1g
Hersteller	MedChem Express
CAS-Nr.	50-18-0
Menge	1 g
Quantity options	100 mg 10 mMx1 mL 1 g 200 mg 500 mg
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Testicular & Prostate Cancer
Typ	Inhibitors
Specific against	other
Purity	99.90
Citations	[1]Schwartz PS, et al. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol. 2001 Dec;60(6):1268-1279.\|[2]al-Jafari AA, et al. Inhibition of human acetylcholinesterase by cyclophosphamide. Toxicology. 1995 Jan 19;96(1):1-6.\|[3]Harris RN, et al. Carbon tetrachloride-induced increase in the antitumor activity of cyclophosphamide in mice: a pharmacokineticstudy. Cancer Chemother Pharmacol. 1984;12(3):167-72.\|[4]Liu P, et al. Administration of cyclophosphamide changes the immune profile of tumor-bearing mice. J Immunother. 2010 Jan;33(1):53-9.\|[5]Dominique A Ramirez, et al. Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics. Drug Metab Dispos. 2019, 47, 3.\|[6]H. Roness, et al. Pharmacological administration of recombinant human AMH rescues ovarian reserve and preserves fertility in a mouse model of chemotherapy, without interfering with anti-tumoural effects. J Assist Reprod Genet. 2019, 36, 9.\|[7]Susana Salva, et al. Probiotic Lactobacillus strains protect against myelosuppression and immunosuppression in cyclophosphamide-treated mice. Int Immunopharmacol. 2014, 22, 1. ACS Appl Bio Mater. 2023 Sep 29.\|ACS Nano. 2025 Feb 4;19(4):4672-4683.\|Apoptosis. 2025 Mar 5.\|Biochem Pharmacol. 2021 Jan;183:114340.\|Biomed Res Int. 13 Jul 2022.\|bioRxiv. 2023 Feb 27.\|BJOG. 2025 Feb 19.\|Breast Cancer Res Treat. 2023 May 19.\|Cell Death Dis. 2020 Nov 12;11(11):976.\|Cell Mol Biol Lett. 2025 Feb 19;30(1):21.\|Cell Rep Med. 2024 Nov 25:101837.\|Cytotechnology. 2025 Apr;77(2):76.\|Eur J Pharm Sci. 2024 Jul 21:106860.\|Evid Based Complement Alternat Med. 2021 Nov 11;2021:1718709.\|Evid Based Complement Alternat Med. 2022 Feb 15;2022:7889199.\|Free Radic Biol Med. 2024 Aug 5:S0891-5849(24)00589-6.\|Heliyon. 2024 Aug 22;10(17):e36664.\|Int J Biol Macromol. 2024 Jul 26:134195.\|Int J Mol Sci. 2023, 24(4), 3818.\|J Clin Invest. 2024 Mar 7:e172716.\|J Med Chem. 2025 Mar 10.\|J Med Food. 2022 Jun 27.\|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.\|J Ovarian Res. 2024 Jan 15;17(1):18.\|Life Sci. 2020 Aug 1;254:117590.\|Mol Biol Cell. 2023 Mar 29;mbcE22110518.\|Nat Commun. 2021 Jan 4;12(1):20.\|Nat Commun. 2023 Apr 13;14(1):2109.\|Oncol Res. 2024 May 23;32(6):1109-1118.\|Open Life Sci. 2023, 18(1).\|Pediatr Res. 2025 Feb 20.\|Phys Med Biol. 2020 Sep 24;65(19):195004.\|Pulm Pharmacol Ther. 2023 Mar 9;102202.\|Saudi J Biol Sci. 2023 Jun 15, 103707.\|SSRN. 2025 Feb 18.\|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.\|Research Square Preprint. 2023 Jul 10.
Smiles	ClCCN(CCCl)P1(OCCCN1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	DNA Alkylator/Crosslinker
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	261.089
Product Description	Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: 33.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage
Clinical information	Launched

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HY-17420-1g-safety-datasheet.pdf