Perindopril

ArtNr	HY-B0130-1ea
Hersteller	MedChem Express
CAS-Nr.	82834-16-0
Menge	1 ea
Quantity options	100 mg 1 ea 25 mg 500 mg 50 mg
Kategorie	Reagents & Chemicals Biochemicals
Typ	Chemicals
Specific against	other
Purity	98.11
Citations	[1]Bhat S A, et al. Angiotensin receptor blockade modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation better than angiotensin-converting enzyme inhibition [J]. Molecular neurobiology, 2016, 53: 6950-6967.\|[2]Wei X, et al. Combination of perindopril erbumine and huangqi-danshen decoction protects against chronic kidney disease via sirtuin3/mitochondrial dynamics pathway [J]. Evidence-Based Complementary and Alternative Medicine, 2022, 2022.\|[3]Afonso T, et al. Pharmacodynamic evaluation of 4 angiotensin‐converting enzyme inhibitors in healthy adult horses [J]. Journal of veterinary internal medicine, 2013, 27(5): 1185-1192.\|[4]Thybo N K, et al. Dose-dependent effects of perindopril on blood pressure and small-artery structure [J]. Hypertension, 1994, 23(5): 659-666.\|[5]Jeffery TK, et al. Perindopril, an angiotensin converting enzyme inhibitor, in pulmonary hypertensive rats: comparative effects on pulmonary vascular structure and function. Br J Pharmacol. 1999 Dec;128(7):1407-18.\|[6]Xiong F, et al. Inhibition of AAA in a rat model by treatment with ACEI perindopril. J Surg Res. 2014 Jun 1;189(1):166-73. Biomed Pharmacother. 2023 Feb 6;160:114370.\|Phytomedicine. 2024 Oct 28:135:156187.\|Biosci Rep. 2021 Oct 29;41(10):BSR20211598.\|Br J Pharmacol. 2021 Mar;178(5):1164-1181.\|Evid-Based Compl Alt. 2022 May 21;2022:5812105.\|Stem Cell Res Ther. 2024 Oct 23;15(1):375.
Smiles	O=C([C@H]1N(C([C@@H](N[C@H](C(OCC)=O)CCC)C)=O)[C@@]2([H])CCCC[C@@]2([H])C1)O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	S-9490
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Angiotensin-converting Enzyme (ACE); NF-κB; Sirtuin; STAT
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	368.47
Product Description	Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension[1][2][3][4].
Manufacturer - Research Area	Cancer; Neurological Disease; Cardiovascular Disease
Solubility	H2O: 100 mg/mL (ultrasonic; warming; heat to 80°C)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Isoform	SIRT3; STAT3
Clinical information	Launched

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HY-B0130-1ea-safety-datasheet.pdf