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Flunarizine (dihydrochloride)

Flunarizine (dihydrochloride)

ArtNr	HY-B0358A-1g
Hersteller	MedChem Express
CAS-Nr.	30484-77-6
Menge	1 g
Quantity options	10 g 10mM/1mL 1 g 500 mg 5 g
Kategorie	Food Safety Histamines Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.87
Citations	[1]Hong-Seob So, et al. Protective effect of T-type calcium channel blocker flunarizine on cisplatin-induced death of auditory cells. Hear Res. 2005 Jun;204(1-2):127-39. [2]Qing Ye, et al. Flunarizine blocks voltage-gated Na(+) and Ca(2+) currents in cultured rat cortical neurons: A possible locus of action in the prevention of migraine. Neurosci Lett. 2011 Jan 10;487(3):394-9. [3]Celia M Santi, et al. Differential inhibition of T-type calcium channels by neuroleptics. J Neurosci. 2002 Jan 15;22(2):396-403. [4]Novalbos J, et al. Effects of dotarizine and flunarizine on chromaffin cell viability and cytosolic Ca2+. Eur J Pharmacol. 1999 Feb 5;366(2-3):309-17. [5]Wan L, et al. Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury. Mediators Inflamm. 2020 Nov 10;2020:3691701.
Smiles	FC1=CC=C(C(N2CCN(C/C=C/C3=CC=CC=C3)CC2)C4=CC=C(F)C=C4)C=C1.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Calcium Channel; Dopamine Receptor; Sodium Channel
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	477.42
Product Description	Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine dihydrochloride is a D2 dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects[1][2][3][4][5].
Manufacturer - Research Area	Neurological Disease; Cardiovascular Disease
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : 1 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Isoform	D2 Receptor; T-type calcium channel
Clinical information	Launched

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HY-B0358A-1g-safety-datasheet.pdf