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Chlorpromazine (hydrochloride) (Standard)

Chlorpromazine (hydrochloride) (Standard)

ArtNr	HY-B0407AR
Hersteller	MedChem Express
CAS-Nr.	69-09-0
Menge	1 ea
Quantity options	1 ea 100 mg 250 mg 25 mg 50 mg
Kategorie	Reagents & Chemicals Standards, Ladders & Markers Other Standards
Typ	Standard
Specific against	other
Purity	0.9
Citations	[1]Kamgar-Dayhoff P, et al. Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment. Oncotarget. 2021 Jul 6;12(14):1406-1426. \|[2]Shin SY, et al. The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells. Carcinogenesis. 2013 Sep;34(9):2080-9. \|[3]Yang Z, et al. Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production. Cell Metab. 2022 Nov 2:S1550-4131(22)00461-2. \|[4]Lee SJ, et al. Mechanism of inhibition by chlorpromazine of the human pain threshold sodium channel, Nav1.7. Neurosci Lett. 2017 Feb 3;639:1-7. \|[5]Thomas D, et al. The antipsychotic drug chlorpromazine inhibits HERG potassium channels. Br J Pharmacol. 2003 Jun;139(3):567-74. \|[6]Suzuki H, et al. Comparison of the anti-dopamine D₂ and anti-serotonin 5-HT(2A) activities of chlorpromazine, bromperidol, haloperidol and second-generation antipsychotics parent compounds and metabolites thereof. J Psychopharmacol. 2013 Apr;27(4):396-400.
Smiles	CN(C)CCCN1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13.Cl
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference Standards
Manufacturer - Targets	5-HT Receptor; Autophagy; Cytochrome P450; Dopamine Receptor; Reference Standards
Shipping Temperature	Room temperature
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	355.33
Product Description	Chlorpromazine (hydrochloride) (Standard) is the analytical standard of Chlorpromazine (hydrochloride). This product is intended for research and analytical applications. Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis[1][2][3][4][5].
Manufacturer - Research Area	Cancer; Neurological Disease; Cardiovascular Disease
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Isoform	5-HT2 Receptor

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