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Ranibizumab Biosimilar - Research Grade Europäischer Partner

ArtNr ICH4031-100mg
Hersteller IchorBio
Menge 100 mg
Quantity options 100 mg 10 mg (2 x 5 mg) 1 g 1 mg 200 mg 20 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Kategorie
Typ Biosimilars
Format Liquid
Specific against Human (Homo sapiens)
Isotype IgG1 Kappa
Purity >95% by SDS-PAGE and HPLC
Citations Giannos, S.A., Kraft, E.R., Luisi, J.D. et al. Topical Solution for Retinal Delivery: Bevacizumab and Ranibizumab Eye Drops in Anti-Aggregation Formula (AAF) in Rabbits. Pharm Res 41, 1247–1256 (2024).
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Vascular endothelial growth factor
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Category
Low endotoxin, Biosimilar, recombinant antibody, Cited
Manufacturer - Isotype
Human IgG1 Kappa
Manufacturer - Targets
VEGF
Manufacturer - Host
Humanized
Shipping Temperature
Blue ice
Storage Conditions
Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation
Phosphate buffered saline (PBS) pH 7.2, with no carrier protein, potassium or preservatives added. BSA and Azide free.
Background
Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab binds to and inhibits the biologic activity of human vascular endothelial growth factor A (VEGF-A). Ranibizumab, which lacks an Fc region, has a molecular weight of approximately 48 kilodaltons and is produced by CHO expression system.
Concentration
1.0 - 5.0 mg/ml
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity
Detects human VEGF. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Ranibizumab.
Purification method
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Use
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Isotype Control
Bulk Human IgG1 Isotype Control (IB1) [ICH2254]
Buffer

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 mg
Lieferbar: In stock
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