U-46619

ArtNr	HY-108566-10mg
Hersteller	MedChem Express
CAS-Nr.	56985-40-1
Menge	10 mg (28.5 mM x 1 mL in Methyl acetate)
Quantity options	10 mg (28.5 mM x 1 mL in Methyl acetate) 1 mg (28.5 mM x 100 uL in Methyl acetate) 5 mg (28.5 mM x 500 uL in Methyl acetate)
Kategorie	Cardiovascular Research Thrombosis & Hemostasis Myocardial Infarction Hypertension Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.0
Citations	[1]Ohkubo S, et al. Thromboxane A2-mediated shape change: independent of Gq-phospholipase C--Ca2+ pathway in rabbit platelets. Br J Pharmacol. 1996 Mar;117(6):1095-104.\|[2]Su L, et al. The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways. Stem Cell Res Ther. 2018 Nov 15;9(1):313.\|[3]Schirner M, et al. U 46619 induces different blood pressure effects in male and female spontaneously hypertensive rats (SHR). Prostaglandins Leukot Essent Fatty Acids. 1993 Jun;48(6):469-73.\|[4]Chen S, et al. Roles of the RhoA-ROCK Signaling Pathway in the Endothelial H2S Production and Vasodilation in Rat Cerebral Arteries. ACS Omega. 2022 May 20;7(22):18498-18508. \|[5]Nie D, et al. Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho. Cancer Res. 2008 Jan 1;68(1):115-21.
Smiles	O=C(O)CCC/C=C\C[C@H]1[C@@]2([H])CO[C@@](C2)([H])[C@@H]1/C=C/[C@@H](O)CCCCC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	9,11-Methanoepoxy PGH2
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Prostaglandin Receptor
Shipping Temperature	Blue Ice
Storage Conditions	Solution, -20°C, 2 years
Molecular Weight	350.49
Product Description	U-46619 (9, 11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation[1][4][5].
Manufacturer - Research Area	Cardiovascular Disease
Solubility	DMSO: 100 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	GPCR/G Protein
Isoform	TXA2/TP
Clinical information	No Development Reported

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HY-108566-10mg-safety-datasheet.pdf