Ponatinib

ArtNr	HY-12047-5mg
Hersteller	MedChem Express
CAS-Nr.	943319-70-8
Menge	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.67
Citations	[1]O'Hare T, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell, 2009, 16(5), 401-412.\|[2]Gozgit JM, et al. Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies. Mol Cancer Ther, 2011, 10(6), 1028-1035.\|[3]Uchida T, et al. Hes1 upregulation contributes to the development of FIP1L1-PDGRA-positive leukemia in blast crisis. Exp Hematol. 2014 May;42(5):369-379.e3. Acta Pharm Sin B. 2023 Oct;13(10):4253-4272. Acta Pharmacol Sin. 2021 Jan;42(1):108-114. Biochem Pharmacol. 2021 Oct:192:114710. Biomed Pharmacother. 2024 Nov:180:117569. Biomed Pharmacother. 2025 Jun 20:189:118246. Biomolecules. 2022 Jun 11;12(6):819. bioRxiv. 2024 Apr 21. bioRxiv. 2025 February 26. bioRxiv. 2025 May 5:2025.04.30.651490. bioRxiv. 2025 Sep 30. Blood Vessel Thromb Hemost. 2025 Nov 17. BMC Chem. 2025 Aug 22;19(1):248. Cancer Discov. 2021 Jan;11(1):126-141. Cancer Sci. 2025 Apr;116(4):1115-1125. Cell Rep Med. 2025 Apr 2:102053. Clin Chim Acta. 2018 May:480:180-185. Commun Biol. 2024 Jul 10;7(1):843. Eur J Pharmacol. 2020 Dec 15;889:173292. Exp Hematol. 2014 May;42(5):369-379.e3. Fundam Clin Pharmacol. 2021 Oct;35(5):919-929. Harvard Medical School LINCS LIBRARY Heliyon. 2024 Sep 28;10(19):e38637. Int J Biol Macromol. 2024 Dec 2:138305. J Chem Eng Data. 2024 Jun 10. J Ethnopharmacol. 2023 Jun 12:309:116275. J Ethnopharmacol. 2024 Apr 6:323:117669. J Ethnopharmacol. 2025 Sep 17;355(Pt A):120621. J Hypertens. 2025 May 1;43(5):827-840. J Inflamm Res. 2025 Jun 26:18:8447-8475. J Med Chem. 2019 May 23;62(10):5006-5024. J Med Chem. 2024 Nov 28;67(22):20571-20579. Leuk Res. 2016 Jun:45:24-32. Neurosci Bull. 2020 Mar;36(3):263-276. Pharmaceuticals (Basel). 2022 Aug 29;15(9):1073. Pharmacogn Mag. 2023 Jul 20. PLoS One. 2021 Sep 30;16(9):e0258140. PLoS One. 2022 Feb 14;17(2):e0263822. PLoS One. 2024 Nov 1;19(11):e0308647. Research Square Preprint. 2021 May. Research Square Print. 2023 Mar 23. Sci Rep. 2025 Jul 2;15(1):22961. Sci Rep. 2025 Oct 16;15(1):36227. Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. Target Oncol. 2020 Oct;15(5):659-671. Technical University of Munich. 24.01.2018. University of Pittsburgh. 2025. Biomaterials. 2022 Oct:289:121800.
Smiles	CC1=C(C=C(C=C1)C(NC2=CC(C(F)(F)F)=C(C=C2)CN3CCN(CC3)C)=O)C#CC4=CN=C5N4N=CC=C5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AP24534
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Category	Reference compound / Active compounds; API
Manufacturer - Targets	Autophagy; Bcr-Abl; FGFR; PDGFR; Src; VEGFR
Manufacturer - HS Code	H301, H311, H315, H319, H331, H335
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	532.56
Product Description	Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Autophagy; Protein Tyrosine Kinase/RTK
Clinical information	Launched
Isoform	PDGFRα; VEGFR2/KDR/Flk-1
UNSPSC Code	12352005
Precautionary	H301, H311, H315, H319, H331, H335

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