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ddATP (trisodium)

ddATP (trisodium)

ArtNr	HY-128036B-5mg
Hersteller	MedChem Express
CAS-Nr.	72029-21-1
Menge	5 mg
Quantity options	100 mg 10 mg 25 mg 27 mg (100 mM * 0.5 mL in Water) 50 mg 54 mg (100 mM * 1 mL in Water) 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]van der Vliet PC, et al. Role of DNA polymerase gamma in adenovirus DNA replication. Mechanism of inhibition by 2',3'-dideoxynucleoside 5'-triphosphates. Biochemistry. 1981 Apr 28;20(9):2628-32. [2]Xu Lan, et al. Simultaneous determination of 2 ,3 -dideoxyinosine and the active metabolite, 2 ,3 -dideoxyadenosine-5 -triphosphate in human peripheral-blood mononuclear cell by HPLC–MS/MS and the application to cell pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:337-42. [3]Jun-Yu Ma, et al. Double-strand breaks induce short-scale DNA replication and damage amplification in the fully grown mouse oocytes. Genetics. 2021 Jun 24;218(2):iyab054. [4]C M Perry, et al. Didanosine. An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease. Drugs. 1996 Dec;52(6):928-62. [5]Hao Z, et al. Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro. Mol Pharmacol. 1988 Oct;34(4):431-5.
Smiles	NC1=NC=NC2=C1N=CN2[C@H](O3)CC[C@H]3COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2',3'-Dideoxyadenosine 5'-triphosphate (trisodium)
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	DNA/RNA Synthesis; HIV
Shipping Temperature	Blue Ice
Storage Conditions	Solution, -20°C, 2 years
Product Description	ddATP (2', 3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2', 3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection[1][2][4].
Manufacturer - Research Area	Infection
Solubility	10 mM in H2O
Manufacturer - Pathway	Anti-infection; Cell Cycle/DNA Damage
Clinical information	No Development Reported

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HY-128036B-5mg-safety-datasheet.pdf