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Angiotensin II human (acetate)

Angiotensin II human (acetate)

ArtNr	HY-13948A-10mg
Hersteller	MedChem Express
CAS-Nr.	68521-88-0
Menge	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Kategorie	Cardiovascular Research Heart Failure Myocardial Infarction Hypertension Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.81
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Hypertension. 1997 Jul;30(1 Pt 1):42-9.\|[7]Daugherty A, et al. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest. 2000 Jun;105(11):1605-12. 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Smiles	O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC=N2)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=CC=C4)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N.CC(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Angiotensin II (acetate),Ang II (acetate),DRVYIHPF (acetate)
Similar products	68521-88-0
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Peptides
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Angiotensin Receptor; Apoptosis
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Molecular Weight	1106.23
Product Description	Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway[1][2][3][4].
Manufacturer - Research Area	Cancer; Endocrinology; Cardiovascular Disease
Solubility	H2O: 5 mg/mL (ultrasonic; warming; heat to 37°C)
Manufacturer - Pathway	Apoptosis; GPCR/G Protein
Isoform	AT1 Receptor; AT2 Receptor
Clinical information	Launched

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