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Dizocilpine (maleate)

Dizocilpine (maleate)

ArtNr	HY-15084-5mg
Hersteller	MedChem Express
CAS-Nr.	77086-22-7
Menge	5 mg
Quantity options	10 mM/1 mL 10 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.99
Citations	[1]Wong EH, et al. The anticonvulsant MK-801 is a potent N-Me-D-Asp antagonist. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8.\|[2]Vardhan Reddy KH, et al. Convergent Strategy to Dizocilpine MK-801 and Derivatives. J Org Chem. 2018 Apr 6;83(7):4264-4269.\|[3]Huettner JE, et al. Block of N-Me-D-Asp-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc Natl Acad Sci U S A. 1988 Feb;85(4):1307-11.\|[4]Thomas DM, et al. MK-801 and dextromethorphan block microglial activation and protect against neurotoxicity. Brain Res. 2005 Jul 19;1050(1-2):190-8.\|[5]Brown TE, et al. The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats. Learn Mem. 2008 Dec 2;15(12):857-65.\|[6]Jiang L, et al. Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-Me-D-Asp receptor activation. Neuroreport. 2017 May 24;28(8):444-450.\|[7]Iijima Y, et al. Modification by MK-801 (dizocilpine), a noncompetitive NMDA receptor antagonist sensitization: evaluation by ambulation in mice. Nihon Shinkei Seishin Yakurigaku Zasshi. 1996 Feb;16(1):11-8. Cell. 2023 Nov 22;186(24):5347-5362.e24.\|Eur J Neurosci. 2024 Jul 23.\|Eur J Pharmacol. 2019 Aug 15;857:172427. \|Evid Based Complement Alternat Med. 2020 Mar 10;2020:3524641.\|Front Cell Dev Biol. 2020 Feb 4;8:24. \|Front Cell Neurosci. 2019 Jun 25;13:276.\|Front Neurosci. 2019 Nov 19;13:1225.\|Life Sci. 2022 Feb 17;295:120419.\|Mol Psychiatry. 2022 Jun 17.\|Neuropharmacology. 2024 Dec 24:110284.\|Neuroreport. 2017 May 24;28(8):444-450. \|Psychoneuroendocrinology. 2024 Oct:168:107138.\|Psychopharmacology (Berl). 2024 Nov 18.\|Res Sq. 2024 Jul 15.\|Sci Bull. 2024 Dec 27:S2095-9273(24)00949-6.\|Basic Clin Neurosci. 2021 Jul.\|Bioorg Med Chem. 2022 Feb 18;59:116675.\|Br J Pharmacol. 2020 Oct;177(20):4720-4733.\|Brain Res. 2023 May 17;1812:148409.\|Cell Biosci. 2023 Mar 16;13(1):57.\|Eur J Pharmacol. 2022 Oct 25;175343.\|Front Biosci (Landmark Ed). 2023 Jul 19, 28(7), 140.\|Int J Mol Sci. 2022 Dec 18;23(24):16150.\|J Cell Mol Med. 2020 Aug;24(16):9287-9299.\|J Med Chem. 2023 May 2.\|J Orthop Surg Res. 2025 Jan 23;20(1):83.\|J Physiol. 2023 Jul 8.\|Mol Neurobiol. 2023 Dec 8.\|Molecules. 2023 Mar 2.\|Nat Neurosci. 2021 Dec 9.\|Neuropharmacology. 2025 Jan 20:110318.\|Neurosci Lett. 2023 Sep 4;137471.\|RSC Adv. 2022 Oct 3;12(43):28098-28103.
Smiles	C[C@]12C3=CC=CC=C3C[C@@H](N2)C4=CC=CC=C14.O=C(O)/C=C\C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(+)-MK 801 Maleate
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	iGluR
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	337.37
Product Description	Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 133.33 mg/mL (ultrasonic)\|Ethanol: 25 mg/mL (ultrasonic)\|H2O: 7.69 mg/mL (ultrasonic)
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Isoform	NMDA Receptor
Clinical information	No Development Reported

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HY-15084-5mg-safety-datasheet.pdf