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Gallocyanine (chloride)

Gallocyanine (chloride)

ArtNr	HY-D0961-5mg
Hersteller	MedChem Express
CAS-Nr.	1562-85-2
Menge	5 mg
Quantity options	100 mg 10 mg 25 mg 50 mg 5 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	92.00
Citations	[1]Thysiadis S, et al., Design and synthesis of gallocyanine inhibitors of DKK1/LRP6 interactions for treatment of Alzheimer's disease. Bioorg Chem. 2018 Oct;80:230-244.\|[2]Wu M, et al., Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis. Nat Commun. 2022 Mar 16;13(1):1371.\|[3]Yang L, et al., Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis. Cell Death Dis. 2020 Oct 4;11(10):827.\|[4]Panasenko O M, et al. Gallocyanine as a Fluorogen for the Identification of NADPH-Dependent Production of Superoxide Anion Radical by Blood Cells[J]. Russian Journal of Bioorganic Chemistry, 2021, 47: 299-306.
Smiles	OC1=C(O)C=C(C(O)=O)C2=C1[O+]=C3C=C(N(C)C)C=CC3=N2.[Cl-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference compound
Manufacturer - Targets	Fluorescent Dye; Wnt; β-catenin
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	336.73
Product Description	Gallocyanine chloride is a synthetic blue dyestuff that can be used as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies. Gallocyanine chloride inhibits DKK1/LRP6 interaction (IC50=6.38 μM), activates Wnt signaling pathway, and causes β-catenin accumulation. Gallocyanine chloride exhibits anti-metastasis, anti-inflammatory and anti-fibrosis activities. Gallocyanine chloride can be used as a fluorescent probe for detection of superoxide anion radicals[1][2][3][4].
Manufacturer - Research Area	Cancer; Inflammation/Immunology; Neurological Disease
Solubility	DMSO: 12.5 mg/mL (ultrasonic)
Manufacturer - Pathway	Others; Stem Cell/Wnt
Clinical information	No Development Reported

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HY-D0961-5mg-safety-datasheet.pdf