2-Oleoylglycerol

ArtNr	HY-W011121-5mg
Hersteller	MedChem Express
CAS-Nr.	3443-84-3
Menge	5 mg (28 mM x 500 uL in Ethanol)
Quantity options	1 mg (28 mM x 100 uL in Ethanol) 5 mg (28 mM x 500 uL in Ethanol)
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.0
Citations	[1]Hansen KB, et, al. 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. J Clin Endocrinol Metab. 2011 Sep;96(9):E1409-17.\|[2]Ghafouri N, et, al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol. 2004 Nov;143(6):774-84.\|[3]Yang M, et al. Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol. Nat Commun. 2023 Jan 16;14(1):228.
Smiles	OCC(CO)OC(CCCCCCC/C=C\CCCCCCCC)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2-OG
Similar products	3443-84-3
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Natural Products
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	GLP Receptor; GPR119; NF-κB; TGF-beta/Smad
Shipping Temperature	Blue Ice
Storage Conditions	Solution, -20°C, 2 years
Molecular Weight	356.55
Product Description	2-Oleoylglycerol (2-OG) is a lipid found in the diet. It is a GPR119 agonist, with an EC50 value of 2.5 μM in activating hGPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol enhances the inflammatory response of macrophages and promotes fibrosis by activating the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway. It also stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. 2-Oleoylglycerol is expected to be used in the research of non-alcoholic steatohepatitis (NASH) [1][2][3].
Manufacturer - Research Area	Metabolic Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling; NF-κB; Stem Cell/Wnt; TGF-beta/Smad
Clinical information	No Development Reported

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