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Mouse Klotho beta / KLB Protein, His Tag Europäischer Partner

ArtNr KLB-M52H7-100ug
Hersteller ACROBiosystems
Menge 100 ug
Quantity options 100 ug 500 ug x 2
Kategorie
Typ Proteins Recombinant
Format Solid
Specific against Mouse (Murine, Mus musculus)
Host HEK293
Konjugat/Tag Unconjugated, HIS
Purity 90%
NCBI NP_112457.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias betaKlotho,beta-klotho,BKL,KLB,klotho beta like,klotho beta-like protein
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Category
Protein / Other Recombinant Proteins
Manufacturer - Conjugate / Tag
C-10xHis, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
110.8 kDa
Manufacturer - Format
Powder
Description
Mouse Klotho beta, His Tag (KLB-M52H7) is expressed from human 293 cells (HEK293). It contains AA Phe 53 - Leu 995 (Accession # Q99N32-1).
Background
KLB (Klotho Beta) is a Protein Coding gene. Among its related pathways are RET signaling and HIV Life Cycle. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and fibroblast growth factor binding. An important paralog of this gene is KL. Klotho Beta is a regulator in multiple metabolic processes, while its role in cancer remains unclear. We found the expression of βKlotho was down-regulated in human hepatocellular carcinoma tissues compared with that in paired adjacent non-tumourous liver tissues. Hepatoma cells also showed decreased expression of βKlotho compared with normal hepatocyte cells. Reintroduction of βKlotho into hepatoma cells inhibited their proliferation.
Molecule
Klotho beta
Exp Region
Phe 53 - Leu 995
Characteristics
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 110.8 kDa. The protein migrates as 125-145 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
1.0 EU per μg
Buffer
PBS, pH7.4
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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