Nivolumab, Anti Human PD1 mAb, Carrier-free (BSA/Glycerol-free)

hPD-1

Nivolumab is a genetically engineered fully human immunoglobulin IgG4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 with immune checkpoint inhibitory and antineoplastic activities.We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.

PDCD1, Homo sapiens (Human)

Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.

PBS, pH 7.6