Anti-Mouse CD106 (VCAM-1) (Clone M/K-2.7) – Purified in vivo PLATINUM™ Functional Grade - 1 mg

IF, in vivo, N

2 - 8°C Wet Ice

CD106 is a single-chain type I glycoprotein with a molecular weight of 110 kDa. It is upregulated inresponse to inflammatory stimuli and cytokines, and it plays an important role in leukocyte adhesion, transmigration, and T-cell proliferation by binding to integrins CD49d/CD29 (VLA-4) and α4β71. It hasimplications in several pathologies, including heart diseases, inflammation, and cancer metastasis2. Theregulation and function of CD106 in immune responses highlight its potential as a therapeutic target intreating these conditions. The M/K-2.7 clone was developed using stromal cells derived from mouse bone marrow as theimmunogen. It has been widely used in various research contexts, particularly in studies involving in vivoVCAM-1 neutralization, immunofluorescence techniques, and more. This clone demonstrates itsversatility across a range of experimental setups and is a valuable tool for investigating vascular celladhesion mechanisms and the inflammatory process. It is particularly useful for research focused oninflammatory processes, immune cell migration, and the study of vascular biology3-6.

≥ 5.0 mg/ml

CD106 is predominantly expressed on activated vascular endothelial cells, as wellas on various other cells including follicular and interfollicular dendritic cells, some macrophages, andbone marrow stromal cells. Its expression can also be found in non-vascular cells within joints, kidneys, muscles, the heart, the placenta, and the brain.