Anti-Mouse CD8 (Lyt 2.1) [Clone 116-13.1] — Purified <i>in vivo</i> GOLD™ Functional Grade - 1.0 mg

Depletion, FC

2 - 8°C Wet Ice

CD8 is an integral membrane protein essential to the immune response1. CD8 acts as a co-receptor for the MHC class I molecule:peptide complex and recruits the Src kinase LCK to thevicinity of the TCR-CD3 complex, leading to activation of cytotoxic T-lymphocytes whichrecognize and eliminate infected cells and tumor cells. CD8+ T cell differentiation is tightlyregulated and the T cell response depends on the antigen encountered. The immune response toacute infection, autoimmunity, graft vs host disease, tumors, chronic infection, and self-toleranceare all affected by CD8 + T cells2.116-13.1 is commonly used for the depletion of CD8+ T cells, such as in studies onallotransplantation tolerance3, 4, 5, CD8+ T cell-mediated antitumor immune response during cancerimmunotherapy6, induction of MHC-mismatched mixed chimerism in NOD mice for the therapyof type I diabetes7, and to better understand the development of autoimmune thyroid disease8.Such depletion studies have shown, for example, that CD8+ T lymphocytes play a role in graft rejection via an indirect pathway4.116-13.1 was first described in Monoclonal Antibodies and T-Cell Hybridomas published in 19839.

≥ 5.0 mg/ml

CD8 is present on thymocytes, T lymphocytes, and natural killer cells.