Anti-Human CD4 (Clone SK3) - Purified No Carrier Protein - 100 µg

All|Primary Monoclonal Antibodies

2 - 8°C Wet Ice

CD4 is a type I transmembrane glycoprotein with four domains and is a member of the Igsuperfamily1, 2. CD4 functions primarily as a coreceptor for the MHC class II molecule-peptide complex3. CD4 initiates the early phase of T-cell activation via its association with the T-cell receptor complex and protein tyrosine kinase Lck. In addition, CD4 functions as a mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Furthermore, HIV displays tropism for CD4+ T cells4 and CD4 acts as the primary receptor for HIV viral entry via binding of its extracellular domain with the HIV-1 gp120 surface glycoprotein2, 3. SK3 can be used as a reference standard in quantitative flow cytometry5, 6 and to study HIV viral entry4. SK3 does not compete for binding with Tregalizumab7. Since the binding site of Tregalizumab is in close proximity to a disulfide bond in domain 2 of CD4, SK3 binds elsewhere in the CD4 protein. Lisco et al give domain 3 as the binding site8.

≥1.0 mg/ml

CD4 is expressed on most thymocytes, a subset of T cells (T helper cells, subsets of memory and regulatory T lymphocytes), monocytes, macrophages, human peripheralblood mononuclear cells, natural killer cells, and may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues.