Anti-Human/Mouse/Rat β-Catenin 1 (Clone 12F7) - Biotin - 100 µg

Primary Monoclonal Antibodies

2 - 8°C Wet Ice

β-catenin is an armadillo protein that binds to numerous partners, including cadherins, adenomatosis polyposis coli, and T-cell factor 1 , and is also a principal component of the Wnt signaling pathway 2 . β-catenin is necessary for embryonic development, organ differentiation and development, bone homeostasis, mammalian hair growth, and adult tissue regeneration. Additionally, β-catenin functions in cell adhesion as part of a cadherin/catenin complex, plays an important role in the structural integrity of squamous epithelial cells 3 , and is involved in synaptic plasticity 1 . β-catenin localizes to the cell cytoplasm, and once activated, translocates to the nucleus, where it activates target genes via TCF/LEF transcription factors

0.5 mg/ml

β-catenin 1 is widely expressed in many tissues, including kidney, lung, adult and developing central nervous system, several hair follicle cell types, colon, corticalneurons, and various cancers.