Anti-Human/Monkey CD40L (CD154) (Clone 5C8)- Recombinant in vivo Functional Grade

All|Primary Monoclonal Antibodies>Immune Checkpoints|Purified in vivo Functional Grade

2 - 8°C Wet Ice

CD154, also known as CD40L, gp39, TRAP, or T BAM is a 39 kDa molecule that plays a vital role in the immune system. It belongs to the tumor necrosis factor (TNF) family and is crucial for the interaction between antigen-specific lymphocytes and antigen-presenting cells1, 2. By binding to CD40 it assists in the costimulation process required for activating T cells and promoting B cell proliferation. CD40L also stimulates the secretion of immunoglobulin and facilitates Ig isotype switching when it binds to CD40 on B-cells3. Moreover, CD40L regulates cytokine production by T cells4. Due to its involvement in immune responses, this molecule is of significant importance for immunological research and therapeutic interventions5, 6.
Clone 5C8 is a mouse monoclonal antibody produced through immunization of BALB/c mice with cells from a mouse myeloma cell line. It specifically recognizes human CD154 and binds to an epitope that differs from the CD40 binding site7, 8.

This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.