Anti-Human/Monkey CD40L (CD154) (Clone 5C8) - PE - 25 µg

All|Primary Monoclonal Antibodies>Immune Checkpoints

2 - 8°C Wet Ice

CD154, also known as CD40L, gp39, TRAP, or T BAM is a 39 kDa molecule that plays a vital role in the immune system. It belongs to the tumor necrosis factor (TNF) family and is crucial for the interaction between antigen-specific lymphocytes and antigen-presenting cells1, 2. By binding to CD40 it assists in the costimulation process required for activating T cells and promoting B cell proliferation. CD40L also stimulates the secretion of immunoglobulin and facilitates Ig isotype switching when it binds to CD40 on B-cells3. Moreover, CD40L regulates cytokine production by T cells4. Due to its involvement in immune responses, this molecule is of significant importance for immunological research and therapeutic interventions5, 6.Clone 5C8 is a mouse monoclonal antibody produced through immunization of BALB/c mice with cells from a mouse myeloma cell line. It specifically recognizes human CD154 and binds to an epitope that differs from the CD40 binding site7, 8.

0.2 mg/ml

CD154 is primarily expressed on activated T-cells but can also be found in other celltypes, including platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, smooth muscle cells, endothelial cells, and epithelial cells.